Autoimmune uveitis is a chronic inflammatory disease of the eye and one of the leading causes of blindness.
Patients are usually treated with corticosteroids and immunosuppressives.. Both classes of drugs are known to cause serious side effects when used for a prolonged time period, needed to treat chronic uveitis. Systemic side effects include osteoporosis, extreme weight gain, diabetes etc. When administered locally to the eye, corticosteroids are known to increase the intra-ocular pressure, which in turn leads to cataract and the necessary surgery in most cases. Since 2016 also the TNF α inhibitor Humira® (Adalimumab) is approved to treat uveitis. However, Humira® has to be injected subcutaneously every second week and suppresses the immune system of the whole body.